Severe liver damage may occur if you take more than 4000 mg of acetaminophen in 24 hours. Take only one product that contains acetaminophen at a time. Always … The maximum daily dose of acetaminophen for a healthy adult who weighs at least 150 pounds is 4000 milligrams (mg). However, in some people, … The generally accepted maximum dose of Tylenol in 24 hours is 4,000 mg for healthy adults—and lower for high-risk groups. Watch out for hidden … … maximum daily amount is 5 doses in 24 hours. IMPORTANT INSTRUCTIONS FOR PROPER USE: Read and follow the label on all TYLENOL® products. Do NOT use with any … adult takes more than 4,000 mg of acetaminophen in 24 hours; child takes more than 5 doses in 24 hours, which is the maximum daily amount … 2012 It is not safe to use more than 4 grams (4,000 milligrams) of acetaminophen in one day (24 hours), as this may increase the risk for serious liver problems. For … The maximum acetaminophen dose for healthy adults is 4,000 mg in 24 hours, though many medical experts recommend a safer 3,000 mg daily cap.